ORYZON to hold multiple corporate activities in January
- 40th Annual J.P. Morgan Healthcare Conference
- Biotech Showcase 2022
- 11th Annual LifeSci Partners Corporate Access Event 2022
- H.C. Wainwright Bioconnect Conference
- BioMed Event 2022 in Paris
MADRID, SPAIN and CAMBRIDGE, MA, UNITED STATES, January 3rd, 2022 - Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a public clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet medical need, announced today that its management will update on corporate progress at several renowned international events in January.
Oryzon will participate at the LifeSci Advisors Annual Corporate Access Event, to be held virtually on January 5-7. During this event Dr. Carlos Buesa, Oryzon’s CEO, will participate in a panel of five European Companies entitled "The Best of Both Worlds: Defining Yourself When You Fit Into More Than One Basket" on January 7 at 10:00 am ET. Click on link to register or for more info about LifeSci’s Corporate Access Event.
Oryzon has been invited to participate at the 40th Annual J.P. Morgan Healthcare Conference, to be held virtually on January 10-13. Click on link for more info about the J.P Morgan conference.
In parallel, the company will attend the digital Biotech Showcase 2022 on January 10-12, where it will hold one-to-one meetings with pharmaceutical companies and global investors and will present a corporate update, which will be available on-demand to all registered attendees. Click on link for more info about the Biotech Showcase conference.
The company will also participate at the H.C.Wainwright Bioconnect Conference, to be held virtually on January 10-13 presenting a corporate update, which will be available to conference attendees from January 10 at 07:00 am ET (On-Demand Session). Click on link for more info about H.C. Wainwright Bioconnect.
Oryzon will also attend the BioMed Event 2022, which will be held on January 26 in Paris, France. Click on link for more info about the BioMed event.
Founded in 2000 in Barcelona, Spain, Oryzon (ISIN Code: ES0167733015) is a clinical stage biopharmaceutical company considered as the European champion in epigenetics. Oryzon has one of the strongest portfolios in the field, with two LSD1 inhibitors, iadademstat and vafidemstat, in Phase II clinical trials and ongoing programs for developing inhibitors against other epigenetic targets. In addition, Oryzon has a strong platform for biomarker identification and performs biomarker and target validation for a variety of malignant and neurological diseases. For more information, visit www.oryzon.com
Iadademstat (ORY-1001) is a small oral molecule, which acts as a highly selective inhibitor of the epigenetic enzyme LSD1 and has a powerful differentiating effect in hematologic cancers (see Maes et al., Cancer Cell 2018 Mar 12; 33 (3): 495-511.e12.doi: 10.1016 / j.ccell.2018.02.002.). A FiM Phase I/IIa clinical trial with iadademstat in R/R AML patients demonstrated the safety and good tolerability of the drug and preliminary signs of antileukemic activity, including a CRi (see Salamero et al, J Clin Oncol, 2020, 38(36): 4260-4273. doi: 10.1200/JCO.19.03250). In a still ongoing Phase IIa trial in elder 1L-AML patients (ALICE trial), iadademstat has shown encouraging safety and efficacy data in combination with azacitidine. Beyond hematological cancers, the inhibition of LSD1 has been proposed as a valid therapeutic approach in some solid tumors such as small cell lung cancer (SCLC), neuroendocrine tumors, medulloblastoma and others. In a Phase IIa trial in combination with platinum/etoposide in second line ED-SCLC patients (CLEPSIDRA trial, finalized), preliminary efficacy results have been reported. In total iadademstat has been tested in four clinical trials in more than 100 patients.
Vafidemstat (ORY-2001) is an oral, CNS optimized LSD1 inhibitor. The molecule acts on several levels: it reduces cognitive impairment, including memory loss and neuroinflammation, and at the same time has neuroprotective effects. In animal studies vafidemstat not only restores memory but reduces the exacerbated aggressiveness of SAMP8 mice, a model for accelerated aging and Alzheimer’s disease (AD), to normal levels and also reduces social avoidance and enhances sociability in murine models. In addition, vafidemstat exhibits fast, strong and durable efficacy in several preclinical models of multiple sclerosis (MS). Oryzon has performed two Phase IIa clinical trials in aggressiveness in patients with different psychiatric disorders (REIMAGINE) and in aggressive/agitated patients with moderate or severe AD (REIMAGINE-AD), with positive clinical results reported in both. Additional finalized Phase IIa clinical trials with vafidemstat include the ETHERAL trial in patients with Mild to Moderate AD, where a significant reduction of the inflammatory biomarker YKL40 has been observed after 6 and 12 months of treatment, and the pilot, small scale SATEEN trial in Relapse-Remitting and Secondary Progressive MS, where antiinflammatory activity has also been observed. Vafidemstat has also been tested in a Phase II in severe Covid-19 patients (ESCAPE) assessing the capability of the drug to prevent ARDS, one of the most severe complications of the viral infection, where it showed significant anti-inflammatory effects in severe Covid-19 patients. Currently, vafidemstat is in two Phase IIb trials in borderline personality disorder (PORTICO) and in schizophrenia patients (EVOLUTION). The company is also deploying a CNS precision medicine approach with vafidemstat in genetically-defined patient subpopulations of certain CNS disorders.
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