LSD1 & Disease

Lysine specific demethylase 1 (LSD1, also known as KDM1A) is a histone modifying enzyme that removes methyl groups, is therefore an “eraser”, and by doing that it regulates the expression of many genes important in the onset and progression of diseases such as cancer, neurodegenerative disorders, viral infections, and others.

 

Selected Recent Publications by independent scientists.

 (please refer to PubMed for a complete and up-to-date list of scientific publications in the LSD1 field)

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade. Sheng W, LaFleur MW, Nguyen TH, Chen S, Chakravarthy A, Conway JR, Li Y, Chen H, Yang H, Hsu PH, Van Allen EM, Freeman GJ, De Carvalho DD, He HH, Sharpe AH, Shi Y. Cell. 2018 Jul 26;174(3):549-563.e19. doi: 10.1016/j.cell.2018.05.052. Epub 2018 Jun 21. PMID: 29937226

Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade. Qin Y, Vasilatos SN, Chen L, Wu H, Cao Z, Fu Y, Huang M, Vlad AM, Lu B, Oesterreich S, Davidson NE, Huang Y. Oncogene. 2018 Aug 15. doi: 10.1038/s41388-018-0451-5. [Epub ahead of print] PMID:30111819

The Histone Demethylase LSD1 Inhibits Tumor Cell Immunogenicity. Cancer Discov. 2018 Aug;8(8):911. doi: 10.1158/2159-8290.CD-RW2018-108. Epub 2018 Jun 29.

ORY-1001: Overcoming the Differentiation Block in AML. Bose P, Konopleva MY. Cancer Cell. 2018 Mar 12;33(3):342-343. doi: 10.1016/j.ccell.2018.02.014. PMID:

Inhibition of lysine-specific demethylase 1 prevents proliferation and mediates cisplatin sensitivity in ovarian cancer cells. Shao G, Wan X, Lai W, Wu C, Jin J, Liu X, Wei Y, Lin Q, Zhang L, Shao Q. Oncol Lett. 2018 Jun;15(6):9025-9032. doi: 10.3892/ol.2018.8511. Epub 2018 Apr 17. PMID:29928330

A comprehensive review of lysine-specific demethylase 1 and its roles in cancer. Hosseini A, Minucci S. Epigenomics. 2017 Aug;9(8):1123-1142. doi: 10.2217/epi-2017-0022. Epub 2017 Jul 12. Review. PMID:28699367

LSD1: biologic roles and therapeutic targeting. Maiques-Diaz A, Somervaille TC. Epigenomics. 2016 Aug;8(8):1103-16. doi: 10.2217/epi-2016-0009. Epub 2016 Aug 1. Review. PMID:27479862